Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway.
| Author | |
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| Abstract | :
Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by sulforaphane (SFN) protects from, and deletion of the Nrf2 gene exaggerates, diabetic cardiomyopathy. Angiotensin II (Ang II) plays a critical role in the development of diabetic cardiomyopathy. Therefore, whether SFN prevents Ang II-induced cardiomyopathy through activation of Nrf2 was examined using wild-type, global deletion of Nrf2 gene (Nrf2-KO) and cardiomyocyte-specific overexpression of Nrf2 gene (Nrf2-TG) mice. |
| Year of Publication | :
2018
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| Journal | :
Redox biology
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| Volume | :
15
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| Number of Pages | :
405-417
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| Date Published | :
2018
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| URL | :
http://linkinghub.elsevier.com/retrieve/pii/S2213-2317(17)30864-9
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| DOI | :
10.1016/j.redox.2017.12.016
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| Short Title | :
Redox Biol
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