Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP.
| Author | |
|---|---|
| Abstract | :
Thioredoxin-interacting protein has emerged as a major factor regulating pancreatic β-cell dysfunction and death, key processes in the pathogenesis of type 1 and type 2 diabetes. Accumulating evidence based on basic, preclinical, and retrospective epidemiological research suggests that TXNIP represents a promising therapeutic target for diabetes. The present review is aimed at providing an update regarding these developments. |
| Year of Publication | :
2018
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| Journal | :
Current opinion in endocrinology, diabetes, and obesity
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| Date Published | :
2018
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| ISSN Number | :
1752-296X
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| URL | :
http://Insights.ovid.com/pubmed?pmid=29356688
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| DOI | :
10.1097/MED.0000000000000391
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| Short Title | :
Curr Opin Endocrinol Diabetes Obes
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