Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Author	: L Galluzzi I Vitale SA Aaronson JM Abrams D Adam P Agostinis ES Alnemri L Altucci I Amelio DW Andrews M Annicchiarico-Petruzzelli AV Antonov E Arama EH Baehrecke NA Barlev NG Bazan F Bernassola MJM Bertrand K Bianchi MV Blagosklonny K Blomgren C Borner P Boya C Brenner M Campanella E Candi D Carmona-Gutierrez F Cecconi FK Chan NS Chandel EH Cheng JE Chipuk JA Cidlowski A Ciechanover GM Cohen M Conrad Cubillos -Ruiz JR PE Czabotar D 'Angiolella V TM Dawson VL Dawson De Laurenzi V R De Maria KM Debatin RJ DeBerardinis M Deshmukh N Di Daniele F Di Virgilio VM Dixit SJ Dixon CS Duckett BD Dynlacht WS El-Deiry JW Elrod GM Fimia S Fulda AJ García-Sáez AD Garg C Garrido E Gavathiotis P Golstein E Gottlieb DR Green LA Greene H Gronemeyer A Gross G Hajnoczky JM Hardwick IS Harris MO Hengartner C Hetz H Ichijo M Jäättelä B Joseph PJ Jost PP Juin WJ Kaiser M Karin T Kaufmann O Kepp A Kimchi RN Kitsis DJ Klionsky RA Knight S Kumar SW Lee JJ Lemasters B Levine A Linkermann SA Lipton RA Lockshin C López-Otín SW Lowe T Luedde E Lugli M MacFarlane F Madeo M Malewicz W Malorni G Manic JC Marine SJ Martin JC Martinou JP Medema P Mehlen P Meier S Melino EA Miao JD Molkentin UM Moll C Muñoz-Pinedo S Nagata G Nuñez A Oberst M Oren M Overholtzer M Pagano T Panaretakis M Pasparakis JM Penninger DM Pereira S Pervaiz ME Peter M Piacentini P Pinton JHM Prehn H Puthalakath GA Rabinovich M Rehm R Rizzuto CMP Rodrigues DC Rubinsztein T Rudel KM Ryan E Sayan L Scorrano F Shao Y Shi J Silke HU Simon A Sistigu BR Stockwell A Strasser G Szabadkai SWG Tait D Tang N Tavernarakis A Thorburn Y Tsujimoto B Turk Vanden Berghe P Vandenabeele MG Heiden A Villunger HW Virgin KH Vousden D Vucic EF Wagner H Walczak D Wallach Y Wang JA Wells W Wood J Yuan Z Zakeri B Zhivotovsky L Zitvogel G Melino G Kroemer
Abstract	: Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
Year of Publication	: 2018
Journal	: Cell death and differentiation
Date Published	: 2018
ISSN Number	: 1350-9047
URL	: http://dx.doi.org/10.1038/s41418-017-0012-4
DOI	: 10.1038/s41418-017-0012-4
Short Title	: Cell Death Differ
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