Transformation of Alkynes into Chiral Alcohols via TfOH-Catalyzed Hydration and Ru-Catalyzed Tandem Asymmetric Hydrogenation.
| Author | |
|---|---|
| Abstract | :
A novel full atom-economic process for the transformation of alkynes into chiral alcohols by TfOH-catalyzed hydration coupled with Ru-catalyzed tandem asymmetric hydrogenation in TFE under simple conditions has been developed. A range of chiral alcohols was obtained with broad functional group tolerance, good yields, and excellent stereoselectivities. |
| Year of Publication | :
2018
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| Journal | :
Organic letters
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| Date Published | :
2018
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| ISSN Number | :
1523-7060
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| URL | :
https://dx.doi.org/10.1021/acs.orglett.8b00034
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| DOI | :
10.1021/acs.orglett.8b00034
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| Short Title | :
Org Lett
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