Dual Effect of Histidine on Polysorbate 20 Stability: Mechanistic Studies.
| Author | |
|---|---|
| Abstract | :
L-Histidine (L-His) and polysorbate 20 (PS20) are two excipients frequently included in parenteral products to stabilize biotherapeutics. The objective of the current work was to investigate the impact of L-His on PS20 stability in aqueous solutions when subjected to forced oxidation and accelerated stability testing. |
| Year of Publication | :
2018
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| Journal | :
Pharmaceutical research
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| Volume | :
35
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| Issue | :
2
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| Number of Pages | :
33
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| Date Published | :
2018
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| ISSN Number | :
0724-8741
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| URL | :
https://dx.doi.org/10.1007/s11095-017-2321-1
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| DOI | :
10.1007/s11095-017-2321-1
|
| Short Title | :
Pharm Res
|
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