An automated synthesizer for electrochemical <sup>18</sup>F-fluorination of organic compounds.
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| Abstract | :
Electrochemical F-fluorination of organic compounds provides a means to synthesize Positron-Emission-Tomography (PET) tracers difficult to obtain otherwise. Here, the first automated synthesizer that enables radiolabeling through carrier-added electrochemical F-fluorination is described. The system provides capabilities for all necessary operations such as drying of cyclotron derived [F]fluoride, electrochemical incorporation of the radioisotope into a precursor molecule, subsequent reactions such as protecting group removals, HPLC-purification and formulation of the final tracer. Demonstrated is the aliphatic electrochemical F-fluorination of methyl 2-(phenylthio)acetate. |
| Year of Publication | :
2017
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| Journal | :
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
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| Volume | :
127
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| Number of Pages | :
245-252
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| ISSN Number | :
0969-8043
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| URL | :
https://linkinghub.elsevier.com/retrieve/pii/S0969-8043(17)30544-4
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| DOI | :
10.1016/j.apradiso.2017.06.028
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| Short Title | :
Appl Radiat Isot
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