No Gut No Gain! Enteral Bile Acid Treatment Preserves Gut Growth but Not Parenteral Nutrition-Associated Liver Injury in a Novel Extensive Short Bowel Animal Model.
| Author | |
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| Abstract | :
Parenteral nutrition (PN) provides nutrition intravenously; however, this life-saving therapy is associated with significant liver disease. Recent evidence indicates improvement in PN-associated injury in animals with intact gut treated with enteral bile acid (BA), chenodeoxycholic acid (CDCA), and a gut farnesoid X receptor (FXR) agonist, which drives the gut-liver cross talk (GLCT). We hypothesized that similar improvement could be translated in animals with short bowel syndrome (SBS). |
| Year of Publication | :
2018
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| Journal | :
JPEN. Journal of parenteral and enteral nutrition
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| Volume | :
42
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| Issue | :
8
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| Number of Pages | :
1238-1251
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| ISSN Number | :
0148-6071
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| URL | :
https://doi.org/10.1002/jpen.1167
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| DOI | :
10.1002/jpen.1167
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| Short Title | :
JPEN J Parenter Enteral Nutr
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