Differential expression of cytochrome P450 omega-hydroxylase isoforms and their association with clinicopathological features in pancreatic ductal adenocarcinoma.
| Author | |
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| Abstract | :
The cytochrome P450 (CYP) superfamily consists of enzymes that catalyze the oxidation of lipids, steroids, and drugs. In particular, the CYP4 family plays an essential role in lipid metabolism by the ω-hydroxylation of terminal ends of fatty acids. Disturbance of this system has been associated with increased angiogenesis, proliferation, and metastasis of several cancers. This study aimed to detect the expression of CYP4 isoforms (CYP4A11, CYP4F2, CYP4F3) in pancreatic ductal adenocarcinoma (PDA) and their association with clinicopathological features. |
| Year of Publication | :
2013
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| Journal | :
Annals of surgical oncology
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| Volume | :
20 Suppl 3
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| Number of Pages | :
S636-43
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| ISSN Number | :
1068-9265
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| URL | :
https://dx.doi.org/10.1245/s10434-013-3128-x
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| DOI | :
10.1245/s10434-013-3128-x
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| Short Title | :
Ann Surg Oncol
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