Cellular oncomiR orthologue in EBV oncogenesis.
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Abstract | :
MicroRNAs are small non-coding RNAs that regulate gene expression at multiple levels. The discovery of virally encoded miRNAs attracted immense attention towards their role in viral replication and pathogenesis. Kaposi's-sarcoma-associated herpes virus encodes miRNA that functions as an orthologue of human cellular miRNA, i.e., hsa-miR-155. Keeping the same view we extended the miRNA-homology search between the miRNAs of humans and Epstein-Barr virus. The In silico analyses shows that EBV encoded miR-BART-5 has a significant 'seed' sequence homology to hsa-miR-18 of humans. Further, the mRNA transcripts of the human genes involved in cellular growth could potentially be targeted by both viral as well as human miRNAs. The known etiological role of hsa-miR-18 as an oncomiR suggests that miR-BART-5 may function as viral oncomiR as observed in EBV-positive gastric carcinoma patients. |
Year of Publication | :
2011
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Journal | :
Computers in biology and medicine
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Volume | :
41
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Issue | :
10
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Number of Pages | :
891-8
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ISSN Number | :
0010-4825
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URL | :
https://linkinghub.elsevier.com/retrieve/pii/S0010-4825(11)00155-7
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DOI | :
10.1016/j.compbiomed.2011.07.007
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Short Title | :
Comput Biol Med
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