Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca<sup>2+</sup>-Dependent Arrhythmia.
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| Abstract | :
Circulating SN (secretoneurin) concentrations are increased in patients with myocardial dysfunction and predict poor outcome. Because SN inhibits CaMKIIδ (Ca/calmodulin-dependent protein kinase IIδ) activity, we hypothesized that upregulation of SN in patients protects against cardiomyocyte mechanisms of arrhythmia. |
| Year of Publication | :
2019
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| Journal | :
Circulation. Arrhythmia and electrophysiology
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| Volume | :
12
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| Issue | :
4
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| Number of Pages | :
e007045
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| ISSN Number | :
1941-3149
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| URL | :
https://www.ahajournals.org/doi/abs/10.1161/CIRCEP.118.007045?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
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| DOI | :
10.1161/CIRCEP.118.007045
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| Short Title | :
Circ Arrhythm Electrophysiol
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