Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus.
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| Abstract | :
The antirelapse drug acamprosate has previously been reported to inhibit activating effects of polyamines on -methyl-D-aspartic acid receptor (NMDAR) function. Because increased synthesis of polyamines has been suggested as a mechanism for potentiation of NMDAR function during ethanol withdrawal, we evaluated the effects of acamprosate, MK-801, and ifenprodil in a cell culture model of ethanol withdrawal-induced neurotoxicity. |
| Year of Publication | :
2002
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| Journal | :
Alcoholism, clinical and experimental research
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| Volume | :
26
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| Issue | :
10
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| Number of Pages | :
1468-78
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| ISSN Number | :
0145-6008
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| DOI | :
10.1097/01.ALC.0000033261.14548.D2
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| Short Title | :
Alcohol Clin Exp Res
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