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Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients.

Author
Abstract
:

Several studies suggest that pathological changes in Alzheimer's disease (AD) brain begin around 10-20 years before the onset of cognitive impairment. Biomarkers that can support early diagnosis and predict development of dementia would, therefore, be crucial for patient care and evaluation of drug efficacy. Although cerebrospinal fluid (CSF) levels of Aβ42, tau, and p-tau are well-established diagnostic biomarkers of AD, there is an urgent need to identify additional molecular alterations of neuronal function that can be evaluated at the systemic level.

Year of Publication
:
2016
Journal
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Free radical biology & medicine
Volume
:
91
Number of Pages
:
1-9
ISSN Number
:
0891-5849
URL
:
https://linkinghub.elsevier.com/retrieve/pii/S0891-5849(15)01146-6
DOI
:
10.1016/j.freeradbiomed.2015.12.004
Short Title
:
Free Radic Biol Med
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