Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake.
| Author | |
|---|---|
| Abstract | :
Mitochondrial uncouplers decrease caloric efficiency and have potential therapeutic benefits for the treatment of obesity and related metabolic disorders. Herein we investigate the metabolic and physiologic effects of a recently identified small molecule mitochondrial uncoupler named SHC517 in a mouse model of diet-induced obesity. |
| Year of Publication | :
2021
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| Journal | :
Metabolism: clinical and experimental
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| Volume | :
117
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| Number of Pages | :
154724
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| ISSN Number | :
0026-0495
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| URL | :
https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(21)00024-X
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| DOI | :
10.1016/j.metabol.2021.154724
|
| Short Title | :
Metabolism
|
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