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Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy.

Author
Abstract
:

Cardiomyocyte hypertrophy is a hallmark of cardiac dysfunction in patients with aortic stenosis (AS), and can be triggered by left ventricular (LV) pressure overload in mice by aortic banding (AB). Syndecan-4 is a transmembrane heparan sulphate proteoglycan which is found increased in the myocardium of AS patients and AB mice. The role of syndecan-4 in cardiomyocyte hypertrophy is not well understood.

Year of Publication
:
2022
Journal
:
Molecular biology reports
Date Published
:
2022
ISSN Number
:
0301-4851
URL
:
https://doi.org/10.1007/s11033-022-07985-y
DOI
:
10.1007/s11033-022-07985-y
Short Title
:
Mol Biol Rep
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