Patterns of Metastatic Spread and Mechanisms of Resistance to Crizotinib in <i>ROS1</i>-Positive Non-Small-Cell Lung Cancer.
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| Abstract | :
The ROS1 tyrosine kinase is activated through ROS1 gene rearrangements in 1-2% of non-small cell lung cancer (NSCLC), conferring sensitivity to treatment with the ALK/ROS1/MET inhibitor crizotinib. Currently, insights into patterns of metastatic spread and mechanisms of crizotinib resistance among ROS1-positive patients are limited. |
| Year of Publication | :
0
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| Journal | :
JCO precision oncology
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| Volume | :
2017
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| Date Published | :
2017
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| Short Title | :
JCO Precis Oncol
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